Proteasome and cell cycle

FEBS Letters

Richter-Ruoff, Birgit¹  Wolf, Dieter H.¹ 

[1] Institut für Biochemie der Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany

关键词: Cell cycle;    Proteasome;    Cyclin;    Yeast;    Saccharomyces cerevisiae;   

DOI  :  10.1016/0014-5793(93)81603-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The cell cycle of eukaryotic cells is strictly regulated. This regulation is performed by a serine/threonine kinase. The different functions of this kinase in the cell cycle are modulated by different cyclins, which fluctuate in concentration (‘cycle’) during the different stages of the cell cycle. Using yeast as a model organism we show here that the activity of the multifunctional proteinase, the proteasome, is directly connected to the function of the mitotic cyclin Clb2. Our studies indicate that the proteasome is the proteolytic regulator of this cyclin and thus a central regulator of the cell cycle.

【 授权许可】

Unknown