The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimXCdc2

FEBS Letters

Fischer, Reinhard¹  Schier, Niklas¹ 

[1] Department of Microbiology, Philipps-University of Marburg and Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, 35043 Marburg, Germany

关键词: Aspergillus;    Development;    Cell cycle;    Sporulation;    Cyclin;    Pcl;    NimX;   

DOI  :  10.1016/S0014-5793(02)02964-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimX^Cdc2 and a G₁/S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimX^Cdc2. We propose that PclA modulates the kinase activity of NimX^Cdc2 during spore formation.

【 授权许可】

Unknown