FEBS Letters | |
The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimXCdc2 | |
Fischer, Reinhard1  Schier, Niklas1  | |
[1] Department of Microbiology, Philipps-University of Marburg and Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, 35043 Marburg, Germany | |
关键词: Aspergillus; Development; Cell cycle; Sporulation; Cyclin; Pcl; NimX; | |
DOI : 10.1016/S0014-5793(02)02964-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimXCdc2 and a G1/S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimXCdc2. We propose that PclA modulates the kinase activity of NimXCdc2 during spore formation.
【 授权许可】
Unknown
【 预 览 】
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