Evolutionary clustering and functional similarity of RNA‐binding proteins

FEBS Letters

Fukami-Kobayashi, Kaoru¹  Gō, Mitiko¹  Tomoda, Shirou¹ 

[1] Department of Biology, Faculty of Science, Nagoya University, Furocho, Chikusaku, Nagoya 464-01, Japan

关键词: RNA-binding domain;    Splicing factor;    Ribonucleoprotein;    Poly(A)-binding protein;    Drosophila sex determinant;    Gene duplication;   

DOI  :  10.1016/0014-5793(93)80749-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

RNA-binding proteins (RNPs) involved in splicing, processing and translation regulation contain one to four RNA-binding domains. We constructed a phylogenetic tree for the RNA-binding domains, including those of poly(A)-binding protein (PABP), splicing factors, chloroplast RNPs, hnRNPs, snRNP U1-70K, nucleolin and Drosophila sex determinants. Proteins with similar functions were found to have closely related RNA-binding domains and common domain organizations. In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs.

【 授权许可】

Unknown