Expression of interleukin‐1α and interleukin‐1 receptor type I genes in murine brown adipose tissue

FEBS Letters

Tvrdí, Petr¹  Burýs̆ek, Ladislav¹  Hous̆tĕk, Josef¹ 

[1] Institute of Physiology, Academy of Sciences of the Czech Republic, Viden̆ská 1083, 142 20 Prague, Czech Republic

关键词: Gene expression;    IL-1α;    IL-1RtI;    Brown adipose tissue;    Cold thermogenesis;    Lipopolysaccharide;    BAT;    brown adipose tissue;    IL-1α;    interleukin-lα;    IL-1RtI;    interleukin-1 receptor type I;    LPL;    lipoprotein lipase;    LPS;    lipopolysaccharide;    UCP;    mitochondrial uncoupling protein;   

DOI  :  10.1016/0014-5793(93)81717-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

At thermoneutral conditions, high steady-state levels of transcripts for both IL-1α and its receptor IL-1RtI were found in specialized thermogenic organ, brown adipose tissue (BAT) of adult mice, as compared with the levels in lymph nodes, brain and spleen. A pronounced decrease of IL-1α mRNA level in BAT was observed after lipopolysaccharide (LPS) administration and after exposure to cold. Likewise, LPS decreased the IL-1 RtI mRNA level and depressed also the expression of cold-inducible genes for the BAT-specific heat-producing uncoupling protein and for lipoprotein lipase. It is concluded that, besides the centrally-mediated effects, there exists a direct peripheral interaction of IL-1 cytokines with BAT cells.

【 授权许可】

Unknown