Attraction of human monocytes by the neuropeptide secretoneurin

FEBS Letters

Hogue-Angeletti, Ruth¹  Wiedermann, Christian J.³  Kähler, Christian M.³  Fischer-Colbrie, Reiner²  Kirchmair, Rudolf²  Reinisch, Norbert³  Winkler, Hans² 

[1] Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA;Department of Pharmacology, University of Innsbruck, Peter-Mayr-Straße 1a, A-6020 Innsbruck, Austria;Department of Internal Medicine, University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria

关键词: Secretoneurin;    Secretogranin II;    Neurogenic inflammation;    Chemotaxis;    Monocyte;   

DOI  :  10.1016/0014-5793(93)81676-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

【 授权许可】

Unknown