A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

FEBS Letters

Fischer, Peter¹  Jellinger, Kurt¹  Lassmann, Hans¹  Weiler, Rosa¹  Winkler, Hans¹ 

[1] Department of Pharmacology, University of Innsbruck, Peter Mayr-Straße la, A-6020 Innsbruck Austria

关键词: Alzheimer's disease;    Pick's disease;    Chromogranin A;    Secretogranin II;    Synaptin/synaptophysin;   

DOI  :  10.1016/0014-5793(90)81408-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Chromogranin A and synaptin/synaptophysin were characterized by immunological methods in human autopsy brain tissue from patients with Alzheimer's and Pick's disease. In immunoblots there was no qualitative difference between the antigens in control and diseased brain, but significant quantitative differences were found. In all Alzheimer cases there was a significantly lower level of synaptin/synaptophysin, whereas chromogranin A was higher in 4 out of 5 cases and in all cases relative to synaptin/synaptophysin. An analogous findingwas obtained for Pick's disease. Immunohistologically a consistent staining of neuritic plaques for chromogranin A, but not for secretogranin II was found in Alzheimer cases. In Pick's disease the characteristic Pick bodies showed an analogous specific immunostaining.

【 授权许可】

Unknown