Association of annexin V with mitochondria

FEBS Letters

Sun, Jiuru¹  Bird, Phillip¹  Salem, Hatem H.¹  Bird, Catherina H.¹ 

[1] Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Box Hill 3128, Australia

关键词: Annexin V;    Mitochondrion;   

DOI  :  10.1016/0014-5793(93)80198-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Annexin V is an intracellular protein recently shown to be localized to nucleoli and cytosol. In this study we show that cytosolic annexin V is associated with mitochondria. To assess the nature of the annexin V-mitochondrial interaction, an annexin V binding activity was partially purified from placental cytosol by annexin V-affinity chromatography. Five polypeptides in the eluate appeared to be associated with annexin V, with a predominant species of 27 kDa. Antibodies to the 27 kDa polypeptide recognised mitochondria but not nucleoli. We conclude that annexin V interacts with a 27 kDa nutochondrial polypeptide that is possibly part of a larger complex.

【 授权许可】

Unknown