Nucleolar and cytoplasmic localization of annexin V

FEBS Letters

Sun, Jiuru¹  Salem, Hatem H.¹  Bird, Philip¹ 

[1] Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Box Hill 3128, Australia

关键词: Annexin V;    Nucleolus;    Endothelial cell;   

DOI  :  10.1016/0014-5793(92)81519-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The subcellular localization of annexin V in cultured human umbilical vein endothelial cells, epithelial cells and fibroblasts was examined. Indirect immunofluorescence and immunoblotting studies using affinity-purified anti-annexin V antibodies revealed that annexin V is located within the cytoplasm and nucleus of these cells. Further examination and direct binding studies showed that annexin V within the nucleus is associated with the nucleolus. These findings suggest that annexin V may play a role in a nucleolar function, such as ribosome assembly and transport.

【 授权许可】

Unknown