Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

FEBS Letters

Omori, Akira¹  Arioka, Manabu²  Sato, Showbu¹  Imahori, Kazutomo¹  Uchida, Tsuneko¹  Kobayashi, Shunsuke³  Shiratsuchi, Akiko¹  Ishiguro, Koichi¹ 

[1] Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan;Department of Agricultural Chemistry, University of Tokyo, Bunkyoku, Tokyo 113, Japan;College of Pharmacy, Nihon University, Narashinodai, Funabashishi, Chiba 274, Japan

关键词: Tau protein;    Protein kinase;    Phosphorylation;    Paired helical filament;    Alzheimer's disease;    Glycogen synthase kinase 3β;   

DOI  :  10.1016/0014-5793(93)81066-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β.

【 授权许可】

Unknown