Adenine dinucleotide‐mediated cytosolic free Ca2+ oscillations in single hepatocytes

FEBS Letters

Cobbold, Peter H.²  Green, Anne K.²  Dixon, C.Jane²  McLennan, Alexander G.¹  Fisher, Michael J.¹ 

[1] Department of Biochemistry, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK;Department of Human Anatomy and Cell Biology University of Liverpool, PO Box 147, Liverpool L69 3BX, UK

关键词: Ca2+ oscillation;    Adenine dinucleotide;    Purinoceptor;    Single hepatocyte;    [Ca2+]free;    cytosolic concentration of free Ca2+;    Ap3A;    diadenosine 5′;    5‴-P 1;    P 3-triphosphate;    Ap4A;    diadenosine 5′;    5‴-P 1;    P 4-tetraphosphate;    ApppsA;    diadenosine 5′;    5‴-P 1;    P 3-(P 1-thio)-triphosphate (mixed isomers);    ApspppsA;    (SpSp)diadenosine 5′;    5‴-P 1;    P 4-dithiotetraphosphate;   

DOI  :  10.1016/0014-5793(93)81567-J

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Single rat hepatocytes microinjected with aequorin respond to Ca²⁺-mobilizing agonists, including ADP and ATP, with oscillations in cytosolic free Ca²⁺. We show here that single rat hepatocytes also respond to the adenine dinucleotides Ap₃A and Ap₄A with Ca²⁺ oscillations which resemble those induced by ADP and ATP.

【 授权许可】

Unknown