The neurotransmitter role of diadenosine polyphosphates

FEBS Letters

Gualix, Javier¹  Miras-Portugal, M.Teresa¹  Pintor, Jesús¹ 

[1] Departamento de Bioquı́mica, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain

关键词: Adenine dinucleotide;    ApnA;    Nucleotide receptor;    Protein kinase;    Protein phosphatase;    Purinergic receptor;   

DOI  :  10.1016/S0014-5793(98)00560-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Diadenosine polyphosphates present at the cytosol can be transported to secretory granules allowing their exocytotic release. Extracellularly, they can act through specific metabotropic or ionotropic receptors, or as analogues of P2X and P2Y nucleotide receptors. The specific ionotropic receptor P4 is present in synaptic terminals, and modulated by protein kinases (PK) A and C and protein phosphatases. Activation of PKA or PKC, directly or through membrane receptors, results in a decrease of affinity or in reduction of the Ca²⁺ transient respectively. Adenosine and ATP, both products of the extracellular destruction of diadenosine polyphosphates, acting through A₁ or P2Y receptors respectively, are important physiological modulators at the P4 receptor.

【 授权许可】

Unknown