Control of muscle pyruvate oxidation during late pregnancy

FEBS Letters

Sugden, Mary C.¹  Holness, Mark J.¹ 

[1] Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary & Westfield College, University of London, Mile End Road, London, E1 4NS, UK

关键词: Pyruvate dehydrogenase complex;    Pyruvate dehydrogenase kinase;    Starvation;    Late pregnancy;    Glucose/fatty acid cycle;    Pyruvate;    GUI;    glucose utilization index;    NEFA;    non-esterified fatty acids;    PDH;    pyruvate dehydrogenase;    PDHa;    the active form of PDH;    TDG;    2-tetradecylglycidate;    TG;    triacylglycerol;   

DOI  :  10.1016/0014-5793(93)80091-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Despite significant increases in circulating concentrations of lipid fuels (triacylglycerol, non-esterified fatty acids (NEFA) and ketone bodies) in late-pregnant rats sampled in the fed (absorptive) state, cardiac and skeletal muscle active pyruvate dehydrogenase (PDH_a) activities remained comparable with those observed in fed, age-matched virgin controls. Cardiac PDH_a activity was suppressed in response to acute (6 h) starvation in late-pregnant (as well as virgin) rats: this inactivation was opposed by inhibition of mitochondrial long-chain FA oxidation. Starvation (6 h) also led to PDH inactivation in skeletal muscles of late-pregnant, but not virgin, rats. Starvation for 24 h led to further suppression of cardiac PDH_a activity and was associated with significant increases in PDH kinase activities in both virgin and late-pregnant rats. Late pregnancy did not itself influence cardiac PDH kinase activity.

【 授权许可】

Unknown