Polysialic acids: potential in drug delivery

FEBS Letters

McCormack, B.¹  Lifely, R.²  Wang, Z.¹  Gregoriadis, G.¹ 

[1] Centre for Drug Delivery Research, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK;The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, UK

关键词: Polysaccharide;    Polysialic acid;    Drug delivery system;    Drug targeting;    Drug clearance;   

DOI  :  10.1016/0014-5793(93)81177-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A number of bacterial polysialic acids were injected intravenously into mice. Half-lives (up to 40 h) in the blood circulation were dependent on the polysialic acid used, increased by deacylation of their phospholipid moiety, decreased with shorter chain derivatives and appeared to be dose independent. A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half-lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological action.

【 授权许可】

Unknown