FEBS Letters | |
Platelet‐derived endothelial cell growth factor Pharmacokinetics, organ distribution and degradation after intravenous administration in rats | |
Usuki, Kensuke2  Heldin, Carl-Henrik2  Waltenberger, Johannes2  Fellström, Bengt1  Funa, Keiko2  | |
[1] Department of Internal Medicine, University Hospital, S-75124 Uppsala, Sweden;Ludwig Institute for Cancer Research, Uppsala Branch, University Hospital, S-75124 Uppsala, Sweden | |
关键词: Angiogenesis; Platelet-derived endothelial cell growth factor; Re-endothelialization of blood vessel; Pharmacokinetics; Thymidine phosphorylase; Chemotherapy; | |
DOI : 10.1016/0014-5793(92)81428-O | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Platelet-derived endothelial cell growth factor (PD-ECGF) stimulates chemotaxis of endothelial cells in vitro and has angiogenic activity in vivo. Recently PD-ECGF was shown to have thymidine phosphorylase activity. In order to study possible therapeutic applications of PD-ECGF we used a rat model to determine its pharmacokinetics and tissue distribution after intravenous injection. [125I]PD-ECGF disappeared from the plasma in a biphasic manner, with estimated distribution and elimination half-lives of 17 min and 7 h, respectively. PD-ECGF was metabolized in the liver, excreted via the bile, and not accumulated in any organ system. The stability and long half-life in the circulation, together with the specificity for endothelial cells, suggest that PD-ECGF may be useful as a therapeutic agent to stimulate re-endothelialization in vivo, or, in view of its thymidine phosphorylase activity, in chemotherapy, by decreasing the pool of available thymidine.
【 授权许可】
Unknown
【 预 览 】
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RO201912020297112ZK.pdf | 288KB | download |