Development of Chiral LC-MS Methods for Small Molecules and their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies.

Desai, M. J.

Technical Information Center Oak Ridge Tennessee

关键词: Pharmacokinetics;    Chromatography;    Mass spectroscopy;    Detection;    Flow rate;   

RP-ID  :  DE2005837266

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

The purpose of this research was to develop sensitive LC-MS methods for enantiomeric separation and detection, and then apply these methods for determination of enantiomeric composition and for the study of pharmacokinetic and pharmacodynamic properties of a chiral nutraceutical. Our first study, evaluated the use of reverse phase and polar organic mode for chiral LC-API/MS method development. Our second study, continued with chiral LC-MS method development in this case for the normal phase mode.