Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain

FEBS Letters

Takeshima, Hiroshi¹  Imoto, Keiji¹  Nakai, Junichi¹  Hakamata, Yasuhiro¹ 

[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto 606-01, Japan

关键词: Ryanodine receptor;    Calcium release channel;    cDNA cloning;    RNA blot hybridization;    Smooth muscle;    Rabbit brain;    ER;    endoplasmic reticulum;    IP3;    inositol 1;    4;    5-tris-phosphate;    SR;    sarcoplasmic reticulum;    T-tubule;    transverse tubule;   

DOI  :  10.1016/0014-5793(92)80941-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The complete amino acid sequence of a novel ryanodine receptor/calcium release channel from rabbit brain has been deduced by cloning and sequence analysis of the EDNA. This protein is composed of 4872 amino acids and shares characteristic structural features with the skeletal muscle and cardiac ryanodine receptors. RNA blot hybridization analysis shows that the brain ryanodine receptor is abundantly expressed in corpus striatum, thalamus and hippocampus, whereas the cardiac ryanodine receptor is more uniformly expressed in the brain. The brain ryanodine receptor gene is transcribed also in smooth muscle.

【 授权许可】

Unknown