Endogenous Xenopus‐oocyte Ca‐channels are regulated by protein kinases A and C

FEBS Letters

Fournier, F.¹  Nargeot, J.¹  Bourinet, E.¹  Charnet, P.¹ 

[1] CNRS-CRBM, Route de Mende BP 5051, 34033 Monttpellier, France

关键词: Calcium channel;    Oocyte;    Phosphorylation;    Protein kinase A;    Protein kinase C;    VDCC;    voltage-dependent calcium channels;    DHP;    di-hydropyridine;    PKA;    protein kinase A;    PKC;    protein kinase C;    Ag.A.V;    Agelenopsis aperta venom;    DAG;    diacylclycerol;    PMA;    phorbol 12-myristate 13-acetate;    OAG;    oleyl-acetyl-glycerol;    IBMX;    3-isobutyl 1-methyl xanthine;    PDBU;    phorbol 12;    13-dibutyrate;   

DOI  :  10.1016/0014-5793(92)80087-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, ω-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.

【 授权许可】

Unknown