期刊论文详细信息
FEBS Letters
Transcription mapping of the Ori L region reveals novel precursors of mature RNA species and antisense RNAs in rat mitochondrial genome
Tullo, A.1  Saccone, C.1  Nardelli, M.2  Tanzariello, F.1  Sbisà, E.2 
[1] Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Trav. 200 Re David 4, I-70125 Bari, Italy;Centro di Studio Mitocondri e Metabolismo Energetico, CNR Bari, Trav. 200 Re David 4, I-70125 Bari, Italy
关键词: Mitochondrial DNA;    Replication;    Regulation;    Antisense RNA;    Transcript processing;    mt;    mitochondrial;    Ori region;    region containing the origin of replication;    H;    heavy;    L;    light;    ND;    NADH dehydrogenase;    CO;    cytochrome oxidase;    D-loop;    displacement loop;    CSB;    conserved sequence block;   
DOI  :  10.1016/0014-5793(92)80311-4
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

We have identified new transcripts in the region surrounding the L-strand replication origin (Ori L) of rat liver mitochondrial DNA. In particular, we have detected previously unidentified intermediates of RNA processing on both the heavy and the light strands, such as precursors of the ND2 mRNA plus the Trp-tRNA and precursors of the tRNAs clustered in the Ori L region. This indicates that the mechanism of RNA processing in mitochondria proceeds step-wise producing a variety of precursors of the mature forms. The other striking finding is the detection of antisense RNA species in the region of L-strand replication. Since a variety of antisense transcripts were also found in the D-loop region of rat mitochondrial DNA, we suggest that they might play a regulatory role in the replication and expression of the mitochondrial genome.

【 授权许可】

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