The protecting effect of L‐carnitine on Ca2+‐loaded rat liver mitochondria

FEBS Letters

Arrigoni-Martelli, E.³  Bobyleva, V.²  Bellei, M.²  Starkov, A.¹  Mokhova, E.²  Dedukhova, V.¹  Muscatello, U.² 

[1] A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, USSR;Institute of General Pathology, Modena, Italy;Institute of General Pathology, Sigma-Tau, Pomesia, Roma, Italy

关键词: Mitochondrion;    Fatty acid;    Ca2+;    Carnitine;    Acyl-CoA;    Uncoupler;    FCCP;    p-trifluoromethoxycarbonylcyanide phenylhydrazone;    DNP;    2;    4-dinitrophenol;    MOPS;    morpholinopropane sulphonate;    BSA;    bovine serum albumin;   

DOI  :  10.1016/0014-5793(91)81066-H

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is shown that L-carnitine strongly increases the ability of rat liver mitochondria to respond to the train of Ca²⁺ additions by a transient stimulation of the State-4 respiration rate. Such an effect requires ATP and the L-carnitine efficiency strongly decreases when ATP is omitted, Oleate influences the mitochondria in a fashion opposite to that of L-carnitine. The oleate effect is strongly diminished by L-carnitine. Again, the L-carnitine effect requires ATP, and D-carnitine fails to substitute for L-carnitine. It is suggested that L-carnitine removes, in an ATP-dependent manner, endogenous or added fatty acids, which are involved in oxidative damage of Ca²⁺-loaded mitochondria.

【 授权许可】

Unknown