FEBS Letters | |
The protecting effect of L‐carnitine on Ca2+‐loaded rat liver mitochondria | |
Arrigoni-Martelli, E.3  Bobyleva, V.2  Bellei, M.2  Starkov, A.1  Mokhova, E.2  Dedukhova, V.1  Muscatello, U.2  | |
[1] A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, USSR;Institute of General Pathology, Modena, Italy;Institute of General Pathology, Sigma-Tau, Pomesia, Roma, Italy | |
关键词: Mitochondrion; Fatty acid; Ca2+; Carnitine; Acyl-CoA; Uncoupler; FCCP; p-trifluoromethoxycarbonylcyanide phenylhydrazone; DNP; 2; 4-dinitrophenol; MOPS; morpholinopropane sulphonate; BSA; bovine serum albumin; | |
DOI : 10.1016/0014-5793(91)81066-H | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
It is shown that L-carnitine strongly increases the ability of rat liver mitochondria to respond to the train of Ca2+ additions by a transient stimulation of the State-4 respiration rate. Such an effect requires ATP and the L-carnitine efficiency strongly decreases when ATP is omitted, Oleate influences the mitochondria in a fashion opposite to that of L-carnitine. The oleate effect is strongly diminished by L-carnitine. Again, the L-carnitine effect requires ATP, and D-carnitine fails to substitute for L-carnitine. It is suggested that L-carnitine removes, in an ATP-dependent manner, endogenous or added fatty acids, which are involved in oxidative damage of Ca2+-loaded mitochondria.
【 授权许可】
Unknown
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