FEBS Letters | |
A 22 kDa polyanion inhibits carnitine‐dependent fatty acid oxidation in rat liver mitochondria | |
Hoppel, Charles1  Kerner, Janos1  Turkaly, Peter1  | |
[1] Department of Veterans Affairs Medical Center, Departments of Nutrition, Medicine and Pharmacology, Medical Research Service (151W), 10701 East Blvd., Case Western Reserve University, Cleveland, OH 44106, USA | |
关键词: Mitochondrion; Carnitine; Fatty acid oxidation; Porin; Polyanion; Carnitine palmitoyltransferase; VDAC; voltage-dependent anion channel (porin); CPT-I; malonyl-CoA sensitive carnitine palmitoyltransferase; PA-22; 22 kDa polyanion; | |
DOI : 10.1016/S0014-5793(99)01354-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The transport of activated fatty acids across the mitochondrial outer membrane has not been fully addressed. A polyanion (M n=22 kDa) inhibited the ADP-stimulated carnitine-dependent oxidation of both palmitoyl-CoA and palmitate plus CoA as well as mitochondrial hexokinase binding. In contrast, the oxidation of palmitoylcarnitine plus malate, as well as glutamate oxidation, was essentially unaffected. Mitochondrial carnitine palmitoyltransferase-1 was not inhibited by the polyanion. The data suggest an additional component in carnitine-dependent mitochondrial fatty acid oxidation, possibly porin.
【 授权许可】
Unknown
【 预 览 】
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