Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor

FEBS Letters

Ito, Nobuyuki²  Hatanaka, Masakazu⁴  Takahashi, Jun A.⁴  Kikuchi, Haruhiko³  Kozai, Yoshio⁵  Oda, Yoshifumi³  Fukumoto, Manabu¹ 

[1] Department of Pathology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan;Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan;Department of Neurosurgery, Faculty of Medicine, Kyoto University, Kyoto 606, Japan;Human Cancer Laboratory, Department of Molecular Virology, Institute for Virus Research, Kyoto University, Kyoto 606, Japan;Central Research Division, Takeda Chemical Industries. Ltd. Osaka 532, Japan

关键词: Basic fibroblast growth Factor;    Fibroblast growth factor receptor;    Mouse monoclonal antibody;    Glioblastoma;    HeLa cell;    FGF;    fibroblast growth factor;   

DOI  :  10.1016/0014-5793(91)81004-R

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage-dependent and anchorage-independent growth of U-87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF remptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development or these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization or basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors.

【 授权许可】

Unknown