Immunohistochemical analysis of ATRX, p53 and IDH Gene mutations in glioblastoma patients and their co-relations with patient survival in Seoul National University Hospital, Seoul, South Korea

Glioblastoma;Loss of ATRX expression;p53 over expression;IDH mutation.;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Glioblastoma;    Loss of ATRX expression;    p53 over expression;    IDH mutation.;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/132788/1/000000066889.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

similarly patients having IDH1 mutant GBM had a better median overall survival of 28.6 months as compared to 15.5 months for GBM patients with wild type IDH1.However, patients showing mutant expression of p53 had a poor overall survival of 15.5 months as compared to 21.6 months for patients who had negative expression of p53. We also found that there were statistically significant survival differences when these genes were analyzes in different two and three gene combinations. While carrying out immunohistochemical and survival outcome analysis in pediatric and adult GBM cases separately we found that immunohistochemically pediatric GBM are different from adult GBM in genetic signature expressions. Survival analysis of adult GBM cases showed similar results as of unselected GBM survival outcome results..Conclusion- Aberrant expressions of ATRX, p53, and IDH encoded by different tumor regulatory genes frequently occur in GBM and also, that mutant ATRX, mutant IDH and negative expression of p53 protein individually and their combinations are associated with statistically better patient outcome, which may be used as prognostic factors in GBM.