Alpha 2‐macroglobulin synthesis in interleukin‐6‐stimulated human neuronal (SH‐SY5Y neuroblastoma) cells Potential significance for the processing of Alzheimer β‐amyloid precursor protein

FEBS Letters

Ganter, Ursula³  Weidemann, Andreas¹  Bauer, Joachim³  Beyreuther, Konrad¹  Strauss, Sylvia²  Jonas, Uwe³  Volk, Benedikt²  Berger, Mathias³ 

[1] Zentrum für Molekulare Biologie Heidelberg, D-6900 Heidelberg, Germany;Abteilung Neuropathologie, Universität Freiburg, D-7800 Freiburg Germany;Psychiatrische Universitätsklinik Freiburg Germany

关键词: Neuron;    Alpha 2-macroglobulin;    Interleukin-6;    Amyloid precursor protein;    Alzheimer's disease;   

DOI  :  10.1016/0014-5793(91)80460-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cultured human neuronal (SH-SY5Y neuroblastoma) cells synthesize and secrete the potent protease inhibitor alpha 2-macroglobulin (a2M) upon stimulation with interleukin-6(IL-6) indicating that alpha 2-macroglobulin behaves as an acute-phase protein in the human central nervous system. Exogenous addition of a2M to the cultured neuronal cells resulted in only a slight inhibition of Alzheimer βA4-amyloid precursor protein (APP) synthesis, but markedly inhibited its secretion pointing to the possibility that a2M may affect the proteolytic APP processing. Evidence is provided that IL-6 and a2M are involved in Alzheimer's disease pathogenesis.

【 授权许可】

Unknown