The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor‐α convertase

FEBS Letters

Karran, Eric H²  Parvathy, S¹  Hooper, Nigel M¹  Turner, Anthony J¹ 

[1] School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK;Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow CM19 5AW, UK

关键词: Zinc metalloproteinase;    Angiotensin converting enzyme;    Tumour necrosis factor-α convertase;    Amyloid precursor protein;    Hydroxamic acid inhibitor;    ACE;    angiotensin converting enzyme;    APP;    amyloid precursor protein;    TNF-α;    tumour necrosis factor-α;   

DOI  :  10.1016/S0014-5793(98)00726-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Angiotensin converting enzyme (ACE) and the Alzheimer's amyloid precursor protein are cleaved from the membrane by zinc metalloproteinases termed ACE secretase and α-secretase, respectively. Tumour necrosis factor-α (TNF-α) convertase (ADAM 17) is a recently identified member of the adamalysin family of mammalian zinc metalloproteinases that is involved in the production of TNF-α and possibly in the cleavage of other membrane proteins. Using two different cell-free assays we were unable to detect significant cleavage and secretion of ACE by TNF-α convertase. In addition, there was a different effect of three hydroxamic acid-based inhibitors (batimastat, compound 1 and compound 4) towards TNF-α convertase as compared to ACE secretase and α-secretase. Thus TNF-α convertase would appear to be distinct from, but possibly related to, the secretases that cleave ACE and the amyloid precursor protein.

【 授权许可】

Unknown