Activation of two angiotensin‐generating systems in the balloon‐injured artery

FEBS Letters

Sakonjo, Hiroshi³  Nishimura, Takayoshi³  Fukamizu, Akiyoshi²  Kikumori, Mikito³  Okunishi, Hideki⁴  Murakami, Kazuo²  Nakagawa, Toshimasa¹  Miyazaki, Mizuo⁴  Shiota, Naotaka⁴ 

[1] Department of Clinical Pathology, Osaka Medical College, Takatsuki 569, Japan;Institute of Applied Biochemistry, University of Tsukuba, Tsukuba 305, Japan;BILIS, Inc., Minakuchi 528, Japan;Department of Pharmacology , Osaka Medical College, Takatsuki 569, Japan

关键词: Angiotensin converting enzyme;    Mast cell chymase;    Chymostatin;    Angiotensin II;    Neointima;    Wound healing;    ACE;    angiotensin converting enzyme;    ANG;    angiotensin;    CAGE;    chymostatin-sensitive angiotensin II-generating enzyme;    PCR;    polymerase chain reaction;    SMC;    smooth muscle cell;   

DOI  :  10.1016/0014-5793(93)81348-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Participation of angiotensin II in the myointimal proliferation following a vascular injury was postulated. This study assessed the potential involvement of the local angiotensin II-forming enzymes in injured arteries of dogs. The potential angiotensin II-forming enzymes are angiotensin-converting enzyme (ACE) and chymostatin-sensitive angiotensin II-generating enzyme (CAGE) which is highly homologous to or could be identical to the mast cell chymase. Both ACE and CAGE catalyze the conversion of angiotensin I to angiotensin II. We found that the enzymatic activities of ACE and CAGE, and the mRNA levels of ACE and chymase were increased in the injury-induced hypertrophied vessels. The results suggest that ACE and CAGE participate in the hypertrophy through the production of angiotensin II which is a growth promoter for vascular smooth muscle cells.

【 授权许可】

Unknown