Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells

FEBS Letters

Ohnaka, Keizo¹  Nawata, Hajime¹  Umeda, Fumio¹  Yamauchi, Teruaki¹  Takayanagi, Ryoichi¹ 

[1] The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University. Maidashi 3-1-1, Fukuoka 812, Japan

关键词: Endothelin;    Endothelial cell;    Glucose;    Diabetes mellitus;    ET;    endothelin;    ET-1-LI;    endothelin-1-like immunoreactivity;   

DOI  :  10.1016/0014-5793(90)80276-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

【 授权许可】

Unknown