Glucose‐enriched medium enhances cell‐mediated low density lipoprotein peroxidation

FEBS Letters

Leflon, P.²  Mazière, J.C.¹  Mazière, C.¹  Auclair, M.¹  Rose-Robert, F.² 

[1] Laboratoire de Chimie-Biologique, Faculté de Médecine Saint-Antoine, 27 rue Chaligny, 75012 Paris, France;Laboratoire de Biochimie, Hôpital Nord, 80054 Amiens, France

关键词: LDL peroxidation;    Glucose;    Endothelial cell;    Smooth muscle cell;    Diabetes mellitus;    Atherosclerosis;    LDL;    low density lipoprotein;    TBARS;    thiobarbituric acid reactive substance (lipid peroxidation end products);   

DOI  :  10.1016/0014-5793(95)00332-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A 1 week preculture of endothelial or smooth muscle cells in glucose-enriched (11.2 to 44.8 mM) media resulted in a marked enhancement of the subsequent ability of cells to oxidize low density lipoprotein, as assessed by the lipid peroxidation end product and conjugated diene content of the particle, its relative electrophoretic mobility and its degradation by macrophages. This phenomenon is correlated to a marked stimulation of superoxide anion secretion by cells. Such an effect of elevated glucose concentration on cell-induced LDL oxidative modification could be involved in the increased occurrence of atherosclerotic lesions in diabetes mellitus.

【 授权许可】

Unknown