FEBS Letters | |
Mastoparan inhibits phosphoinositide hydrolysis via pertussis toxin‐intensive G‐protein in human astrocytoma cells | |
Nakahata, Norimichi1  Matsuoka, Isao1  Nakanishi, Hironori1  Abe, Marilene Tamiko1  | |
[1] Department of Pharmacology, Fukushima Medical College, Hikarigaoka 1, Fukuishima 960-12, Japan | |
关键词: Mastoparan; Phospholipase C; GTP binding protein; Pertussis toxin; Inositol phosphate; IAP; islet activating protein (pertussis toxin); GTPγS; guanosine 5'-[γ-thio]triphosphate; G-protein; guanine nucleotide regulatory protein; cyclic AMP; adenosine 3'; 5'-mono-phosphate; DMEM; Dulbecco's modified Eagle's medium; EMEM; Eagle's minimum essential medium; | |
DOI : 10.1016/0014-5793(90)80074-S | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Mastoparan inhibited [3H]inositol phosphate accumulation induced by carbachol as well as cyclic AMP accumulation induced by isoproterenol in 1321N1 human astrocytoma cells. Mastoparan inhibited GTPγS-induced, but not Ca2+-induced, [3H]inositol phosphate accumulation in membrane preparations with an IC 50 of approximately 10 μM. The inhibitory effect of mastoparan on carbachol-induced [3pH]inositol phosphate accumulation was resistant to pertussis toxin (IAP) treatment in intact cells. These results suggest that mastoparan inhibits phospholipase C in human astrocytoma cells via a GTP binding protein, which is not a substrate for IAP.
【 授权许可】
Unknown
【 预 览 】
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