期刊论文详细信息
FEBS Letters | |
δ Opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes | |
Fukushima, Nobuyuki1  Ueda, Hiroshi1  Misu, Yoshimi1  Miyamae, Takeaki1  | |
[1] Department of Pharmacology, Yokohama City University School of Medicine, Yokohama 236, Japan | |
关键词: δ-Opioid receptor; Pertussis toxin; GTP-binding protein; Signal transduction; Phospholipase C; Xenopus oocyte; | |
DOI : 10.1016/0014-5793(93)80677-M | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Cloned mouse δ-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction. Opioid δ-agonists evoked a calcium-dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the α subunit of Gi1. The δ-agonist-induced current was blocked by naltrindol, a δ-specific antagonist. The δ-agonist evoked no or very weak currents in oocytes with the α subunit of Gq or Go. These findings indicate the functional coupling between the opioid δ-receptor and phospholipase C through an activation of Gi.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020298665ZK.pdf | 445KB | download |