FEBS Letters | |
Direct activation of GTP‐binding regulatory proteins (G‐proteins) by substance P and compound 48/80 | |
Bronner, C.1  Mousli, M.1  Rouot, B.1  Landry, Y.1  Bockaert, J.2  | |
[1]Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur - Strasbourg I, IllkirchFrance | |
[2]Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France | |
关键词: G-protein; Substance P; Compound 48/80; Mastoparan; Mast cell; Go; Gi; Gs and Gt; GTP-binding regulatory proteins; GTPγS; guanosine-5 '-O-(3-thiotriphosphate); PTX; Bordetella pertussis toxin; | |
DOI : 10.1016/0014-5793(90)80023-C | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The neuropeptide substance P and the polyamine compound , both known to activate mast cell secretory processes, increased the rate of GTPγS binding to G-proteins purified from calf brain (Go/Gi mixture). The GTPase activity of G-proteins was also increased by substance P and compound in a dose-dependent and Mg2+-dependent way. These effects were similar to those of the wasp venom peptide rnastoparan, another histamine releaser of rat peritoneal and human skin mast cells. This suggests that the secretory property of compound and substance P is not due to a receptor-mediated process but, like mastoparan, results from a direct activation of G-proteins.
【 授权许可】
Unknown
【 预 览 】
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