A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR‐I and Fas

FEBS Letters

Chapman, Barbara S.¹ 

[1] Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, CA 94143-0446, USA

关键词: Neurotrophin receptor;    NGF receptor;    Molecular modeling;    Apoptosis;    Alpha-helix;    Mastoparan;    NTR;    75 kDa neurotrophin receptor;    TNFR;    tumor necrosis factor receptor;    GDP;    guanosine diphosphate;    G-protein;    heterotrimeric guanine nucleotide-binding regulatory protein;   

DOI  :  10.1016/0014-5793(95)01113-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Members of the NTR/TNFR family mediate apoptosis in many tissues, yet sequence homology has not been detected in their intracellular domains except for a ‘death domain’ in TNFR-I and Fas. Here, a region of the 75 kDa neurotrophin receptor (NTR) has been aligned with this apoptosis-inducing motif. Peptides at the carboxyl terminus of each domain potentially form amphiphilic helices, one of which (in NTR) resembles mastoparan, a G-protein activating peptide. Molecular models of three death-region peptides suggest that observed sequence similarities reflect a common structure, perhaps capable of undergoing an induced coil to helix transition.

【 授权许可】

Unknown