期刊论文详细信息
FEBS Letters
Correlation of trenalose content and heat resistance in yeast mutants altered in the RAS/adenylate cyclase pathway: is trehalose a thermoprotectant?
Hottiger, Thomas1  Wiemken, Andres1  Boller, Thomas1 
[1] Department of Botany, University of Basel, Basel, Switzerland
关键词: Trehalose;    Heat shock;    Thermotolerance;    RAS;    Adenylate cyclase;    cyclic AMP;   
DOI  :  10.1016/0014-5793(89)81139-1
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Trehalose content and thermotolerance were closely correlated in wild type yeast (Saccharomyces cerevisiae) and in cyr1-2 and bcy1-1 mutants both during exponential growth at 27°C and during heat shock at 40°C. Trehalose levels were high when heat shock proteins (hsps) were expected to be induced and low when hsps were presumably absent. It was tried to uncouple trehalose biosynthes and hsp-induction. Various non-heat stresses affected trehalose levels of wild type cells in a similar way as they would have affected hsps. However, no trehalose was accumulated when cells were treated with canavanine, a well-known inducer of hsps but not of the thermotolerant state.

【 授权许可】

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