An endogenous ‘hypertensive factor’ enhances the voltage‐dependent calcium current

FEBS Letters

Johnson, Edwin C.¹  McCumbee, William D.¹  Becker, James B.¹  Reichenbecher, Vernon E.¹  Todd, Daniel G.¹  Wright, Gary L.¹  Simmons, Mark A.¹ 

[1]Biomedical Sciences Graduate Program, Marshall University School of Medicine, Huntington, WV 25755, USA

关键词: Ca2+ current;    Ca2+ channel;    Hypertension;    HF;    hypertensive factor;    I Ca;    calcium current;   

DOI  :  10.1016/0014-5793(89)81025-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of an immunoaffinity-purified putative endogenous hypertensive factor (HF) on voltage-dependent calcium current in frog cardiac myocytes were assessed. In 9 out of 10 cells, HF reversibly increased the peak amplitude of the calcium current. HF increased peak calcium current density at −5 mV from a control level of 1.8 ± 1.3 pA/pF (mean ± SD) to 4.4 ± 2.0 pA/pF. HF shifted the peak of the calcium current-voltage relationship in the hyperpolarizing direction. HF shifted the voltage dependence of the inactivation of the calcium current to more negative potentials with prepulses from −80 to 0 mV, but the inactivation was not affected with prepulses more positive than 0 mV. Modulation of the voltage-dependent calcium current by HF may be the mechanism underlying its pressor effects.

【 授权许可】

Unknown