The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons

FEBS Letters

Mikhaleva, I.I.¹  Kokoz, Yu.M.²  Alekseev, A.E.²  Lankina, D.A.²  Ivanov, V.T.¹  Korystova, A.F.²  Zenchenko, K.I.²  Ziganshin, R.H.¹ 

[1] Peptides Chemistry Laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia;Regulation of Ionic Currents Group, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia

关键词: Hibernation;    Peptide;    Ca2+ current;    Cardiocyte;    Patch clamp;    Septal neuron;   

DOI  :  10.1016/S0014-5793(97)00607-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca²⁺ current were studied. TSKYR activated Ca²⁺ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca²⁺ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca²⁺ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.

【 授权许可】

Unknown