Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscles

FEBS Letters

Caterson, Ian D.¹  Denyer, Gareth S.¹  Lam, David¹  Cooney, Gregory J.¹ 

[1] Departments of Endocrinology and Medicine, Royal Prince Alfred Hospital and The University of Sydney, Sydney, NSW 2006, Australia

关键词: Pyruvate dehydrogenase complex;    Skeletal muscle;    Starvation;    Insulin;   

DOI  :  10.1016/0014-5793(89)80777-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The in vivo responses of pyruvate dehydrogenase (PDH) complex to starvation and insulin was assessed in heart, diaphragm and red quadriceps muscle. PDH complex activity was decreased by starvation (3.4–10.2-fold), the magnitude of change depending on muscle type. Insulin increased PDH activity in all muscle types. In fed rats, this effect was relatively small (1.25–1.29-fold). In starved rats there were effects in heart (4.3-fold) and red quadriceps (1.7-fold) but no effect in diaphragm. These results demonstrate that PDH complex in different groups of muscle has different insulin sensitivity (particularly in tissues from starved animals).

【 授权许可】

Unknown