FEBS Letters | |
Drug targeting in Leishmania donovani infections using tuftsin‐bearing liposomes as drug vehicles | |
Agrawal, A.K.1  Gupta, C.M.1  Guru, P.Y.1  Singha, U.K.1  Singhal, A.1  | |
[1] Divisions of Membrane Biology and Parasitology, Central Drug Research Institute, Lucknow 226 001, India | |
关键词: Leishmania infection; Drug targeting; Liposome; Tuftsin; Immunomodulation; (Macrophage); | |
DOI : 10.1016/0014-5793(89)80222-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The efficacy of sodium stibogluconate against Leishmania donovani infections was markedly enhanced by encapsulating this drug in tuftsin-bearing liposomes. Also, pretreatment of the animals with these liposomes (free of drug) rendered them resistant to this infection, possibly by activating the host's macrophages. These results demonstrate that tuftsin-bearing liposomes besides delivering the drug to the target cells could also enhance the nonspecific resistance against infections, thus offering an additional advantage over the use of tuftsin-free liposomes as drug carriers in leishmania therapy.
【 授权许可】
Unknown
【 预 览 】
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