Drug targeting in Leishmania donovani infections using tuftsin‐bearing liposomes as drug vehicles

FEBS Letters

Agrawal, A.K.¹  Gupta, C.M.¹  Guru, P.Y.¹  Singha, U.K.¹  Singhal, A.¹ 

[1] Divisions of Membrane Biology and Parasitology, Central Drug Research Institute, Lucknow 226 001, India

关键词: Leishmania infection;    Drug targeting;    Liposome;    Tuftsin;    Immunomodulation;    (Macrophage);   

DOI  :  10.1016/0014-5793(89)80222-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The efficacy of sodium stibogluconate against Leishmania donovani infections was markedly enhanced by encapsulating this drug in tuftsin-bearing liposomes. Also, pretreatment of the animals with these liposomes (free of drug) rendered them resistant to this infection, possibly by activating the host's macrophages. These results demonstrate that tuftsin-bearing liposomes besides delivering the drug to the target cells could also enhance the nonspecific resistance against infections, thus offering an additional advantage over the use of tuftsin-free liposomes as drug carriers in leishmania therapy.

【 授权许可】

Unknown