Protection of mice against Plasmodium berghei infection by a tuftsin derivative

FEBS Letters

Gupta, C.M.¹  Bali, Anu¹  Anand, Nitya¹  Puri, Anju¹  Jain, Rakesh K.¹ 

[1] Divisions of Biochemistry and Medicinal Chemistry, Central Drug Research Institute, Lucknow-226 001, India

关键词: Protozoan infection Immunomodulation Tuftsin Liposome Macrophage;   

DOI  :  10.1016/0014-5793(86)80927-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In Plasmodium berghei infections, the mortality rate and parasitaemias were significantly reduced and the mean survival time was considerably enhanced by pretreating the animals with a tuftsin derivative, Thr-Lys-Pro-Arg-NH-(CH₂)2-NHCOC₁₅H₃₁. This effect of the modified tuftsin was further increased upon its incorporation in the liposome bilayer. These results indicate that tuftsin and its derivatives may prove useful in enhancing nonspecific host resistance against protozoan infections.

【 授权许可】

Unknown