Modelling basic features of specificity in DNA‐aureolic acid‐derived antibiotic interactions

FEBS Letters

Gresh, N.¹  Zakrzewska, K.¹  Pullman, B.¹  Hui, X.¹  Chen, K.-X.¹ 

[1] Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, 13, rue Pierre et Marie Curie, 75005 Paris, France

关键词: Antitumor antibiotic;    Groove binding;    Minor groove GC specificity;   

DOI  :  10.1016/0014-5793(89)80209-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC)₂, d(TATATAT)₂, and d(CICICIC)₂, is investigated. A significant preference is displayed for the minor groove of the d(CG) sequence. This is due predominantly to the formation of H-bonds between the hydroxyl groups on the aglycone of the drug and the 2-amino group of the central guanine of the oligonucleotide.

【 授权许可】

Unknown