Thermodynamics of interaction and structure of DNA complexes with phenacylimidazo[5,1-a]isoquinoline derivatives

17th Russian Youth Conference on Physics and Astronomy

物理学;天文学

Osinnikova, D.N.^1 ; Moroshkina, E.B.^1 ; Glushkina, D.M.^1

St. Petersburg State University, 1 Ul'ianovskaia str., Peterghof, St. Petersburg

198504, Russia^1

关键词: Binding modes;    Calf thymus DNA (ct-DNA);    Classical model;    DNA molecules;    Groove binding;    Isothermal titration calorimetry;    Mode of binding;    Partial intercalation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/661/1/012020/pdf
DOI  :  10.1088/1742-6596/661/1/012020

学科分类：天文学(综合)

来源: IOP

【 摘 要 】

Interaction of native calf thymus DNA (ctDNA) with phenacylimidazo[5,1- a]isoquinoline derivatives was studied by the methods of spectrophotometry, viscometry, isothermal titration calorimetry (ITC) and dynamic birefringence. It was found that both of investigated compounds form complexes with the DNA molecule, the structure of compounds affects the mode of binding these ligands to DNA. The primary binding mode can not be described by the classical models of groove binding or intercalation. It has been suggested that the primary mode of binding is partial intercalation.