Mitomycin C‐induced deoxyribose degradation inhibited by superoxide dismutase

FEBS Letters

Quinlan, Gregory J.¹  Wilkins, Stephanie¹  Gutteridge, John M.C.¹ 

[1] Division of Antibiotics and Chemistry, National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, England

关键词: Semiquinone radical;    Antitumor antibiotic;    Hydroxyl radical;    Superoxide dismutase;    Deoxyribose degradation;    TBA-reactivity;   

DOI  :  10.1016/0014-5793(84)80828-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mitomycin C stimulates deoxyribose degradation with the release of thiobarbituric acid-reactive material under conditions of low oxygen concentration. This damage is inhibited by scavengers of the hydroxyl radical, iron chelators and the specific proteins catalase and superoxide dismutase. The reactive radical species appears to arise from a Fenton-type sequence in which iron is reduced by the mitomycin C semiquinone radical.

【 授权许可】

Unknown