期刊论文详细信息
FEBS Letters
Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levels
Gutteridge, John M.C.1 
[1] National Institute for Biological Standards and Control, Holly Hill, Hampstead London NW3 6RB, England
关键词: Superoxide dismutase;    Fenton reaction;    Hydroxyl radical;    Iron chelate;    Deoxyribose degradation;   
DOI  :  10.1016/0014-5793(85)80732-8
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Superoxide dismutase (SOD) completely inhibits the damage caused by a ferric-EDTA chelate in the presence of a superoxide-generating system. In this reaction Superoxide is enzymically dismuted to hydrogen peroxide. Since hydrogen peroxide and a ferric-EDTA chelate are themselves a hydroxyl radical-generating system, it follows that SOD must also protect against damage done by this reaction. The ability of SOD to inhibit damage to deoxyribose caused by hydrogen peroxide and a ferric-EDTA chelate is experimentally demonstrated in this paper.

【 授权许可】

Unknown   

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