Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levels

FEBS Letters

Gutteridge, John M.C.¹ 

[1] National Institute for Biological Standards and Control, Holly Hill, Hampstead London NW3 6RB, England

关键词: Superoxide dismutase;    Fenton reaction;    Hydroxyl radical;    Iron chelate;    Deoxyribose degradation;   

DOI  :  10.1016/0014-5793(85)80732-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Superoxide dismutase (SOD) completely inhibits the damage caused by a ferric-EDTA chelate in the presence of a superoxide-generating system. In this reaction Superoxide is enzymically dismuted to hydrogen peroxide. Since hydrogen peroxide and a ferric-EDTA chelate are themselves a hydroxyl radical-generating system, it follows that SOD must also protect against damage done by this reaction. The ability of SOD to inhibit damage to deoxyribose caused by hydrogen peroxide and a ferric-EDTA chelate is experimentally demonstrated in this paper.

【 授权许可】

Unknown