Oxidation of nitroxide radicals by an iron‐hydrogen peroxide‐amino acid system

FEBS Letters

Nagatoshi, Akiyoshi¹  Yamaguchi, Takeo¹  Kimoto, Eiji¹ 

[1] Department of Chemistry, Faculty of Science, Fukuoka University, Jonan-ku, Fukuoka 814-01, Japan

关键词: Nitroxide radical oxidation;    Amino acid;    Fenton reaction;    Hydroxyl radical;    ESR;    13C-NMR;   

DOI  :  10.1016/0014-5793(85)80120-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The oxidation of nitroxide radicals by the reaction of hemoglobin with hydrogen peroxide occurred using both FeSO₄ and amino acids instead of hemoglobin. Tyrosine, phenylalanine, tryptophan, methionine and cysteine in globin were connected with the formation of the oxoammonium cation. Of these amino acids, tyrosine was especially effective in its oxidation. It was found that both the binding of nitroxide radicals to ferric iron and the activation of amino acids by hydroxyl radicals were important in the radical oxidation.

【 授权许可】

Unknown