Groove selectivity in the interaction of 9‐aminoacridine‐4‐carboxamide antitumor agents with DNA

FEBS Letters

Gresh, N.¹  Pullman, B.¹  Chen, K.-X.¹ 

[1] Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, 13, rue Pierre et Marie Curie, 75005 Paris, France

关键词: Antitumor drug;    Intercalation;    Groove binding;   

DOI  :  10.1016/0014-5793(87)80485-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Theoretical quantitative evaluation of the intercalative binding to DNA of the new antitumor drug 9-amino-acridine-4-carboxamide indicates that, in contradiction with a recently proposed model, the compound should show specificity for interaction with the major (and not minor) groove of GC sequences.

【 授权许可】

Unknown