Phospholipase activation, free fatty acids and the proton permeability of a biological membrane

FEBS Letters

Dix, James A.¹  Teibel, Jeffrey L.¹  Lachowiez, Robert M.¹  Hammoud, Nasser M.¹ 

[1] Department of Chemistry, State University of New York, Binghamton, NY 13901, USA

关键词: Proton transport;    Fatty acid;    Phospholipase;    Plasma membrane vesicle;    Mercuric chloride;    Ca2+;   

DOI  :  10.1016/0014-5793(88)81332-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The rate of collapse of a proton gradient across the apical membrane of rat kidney proximal tubule increases upon treatment with calcium, mercuric chloride and mellitin, substances which activate phospholipase A₂. Treatment with phospholipase A₂ or oleic acid also enhances the rate of proton gradient dissipation. Membrane water permeability is not affected. This phenomenon may have implications in pathological states arising from ischemia or toxic exposure.

【 授权许可】

Unknown