cDNA sequence of the β2‐subunit of human liver alcohol dehydrogenase

FEBS Letters

Ehrig, Torsten¹  von Wartburg, Jean-Pierre¹  Wermuth, Bendicht¹ 

[1] Institut für Biochemie und Molekularbiologie der Universität Bern, Bühlstr. 28, 3012 Bern, Switzerland

关键词: Alcohol dehydrogenase;    cDNA;    NAD+ binding site;    Amino acid substitution;    (Human liver);   

DOI  :  10.1016/0014-5793(88)81301-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA library of mRNA from a human liver expressing the β₂-subunit of alcohol dehydrogenase was constructed in λgt11. One clone coding for 352 of a total of 374 amino acid residues of the β₂-subunit was isolated. The sequence differed from that of the β₁-subunit at one nucleotide position resulting in an Arg/His exchange at position 47 of the peptide chain, in agreement with data from protein sequence analysis [(1984) FEBS Lett. 173, 360–366].

【 授权许可】

Unknown