Iron‐ and manganese‐containing superoxide dismutases can be distinguished by analysis of their primary structures

FEBS Letters

Blake, Colin C.F.¹  Parker, Michael W.² 

[1] European Molecular Biology Laboratory (EMBL), 6900 Heidelberg, FRG;Laboratory of Molecular Biophysics, University of Oxford, Oxford, England

关键词: Iron;    Manganese;    Superoxide dismutase;    Amino acid sequence;    Sequence homology;   

DOI  :  10.1016/0014-5793(88)81160-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The iron- and manganese-containing superoxide dismutases have very similar three-dimensional structures but can be distinguished by various biochemical means. The primary structures of six manganese-containing and three iron-containing superoxide dismutases are known. Analysis of the aligned amino acid sequences of these enzymes taken together with structural data from X-ray diffraction studies demonstrates that the two classes of enzyme can be distinguished on the basis of a small number of single-site substitutions that are positioned in and close to the active site of the enzyme.

【 授权许可】

Unknown