Molecular cloning and sequencing of cDNA for rat cathepsin H Homology in pro‐peptide regions of cysteine proteinases

FEBS Letters

Katunuma, Nobuhiko²  Kawasaki, Hiroshi¹  Minami, Yasufumi¹  Ohno, Shigeo¹  Imajoh, Shinobu¹  Kominami, Eiki²  Emori, Yasufumi¹  Suzuki, Koichi¹  Ishidoh, Kazumi¹ 

[1] Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, 3-18 Honkomagome, Bunkyo-ku, Tokyo 113, Japan;Department of Enzyme Chemistry, Institute of Enzyme Research, The University of Tokushima, Tokushima 770, Japan

关键词: Cathepsin H;    Cysteine proteinase;    cDNA cloning;    Propeptide region;    Amino acid sequence;   

DOI  :  10.1016/0014-5793(87)80545-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA for rat cathepsin H was isolated and sequenced. The deduced protein comprising 333 amino acid residues is composed of a typical signal sequence (21 residues), a pro-peptide region (92 residues) and a mature enzyme region (220 residues). The amino acid sequence in the pro-peptide region, in particular, residues Phe-(−41) to Ser-(−29) of cathepsin H, is highly homologous to the pro-peptide regions of other cysteine proteinases. This homologous region may play a role in the processing of cysteine proteinases.

【 授权许可】

Unknown