Gene structure of rat cathepsin H

FEBS Letters

Katunuma, Nobuhiko²  Kominami, Eiki²  Suzuki, Koichi¹  Ishidoh, Kazumi¹ 

[1] Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, 3-18 Honkomagome, Bunkyo-ku, Tokyo 113, Japan;Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770, Japan

关键词: Cathepsin H;    Cysteine proteinase;    Gene structure;    kbp;    kilo base pairs;    bp;    base pairs;    CANP;    calcium activated neutral proteinase;    the same as calpain;    CP1;    cysteine proteinase 1;    CP2;    cysteine proteinase 2;   

DOI  :  10.1016/0014-5793(89)80939-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gene structure of rat cathepsin H was determined. It comprises at least 12 exons of various lengths (32–433 bp) spanning in total more than 17.5 kbp. The gene structure does not correspond well to the functional unit of the proteinase. The region around the active site Cys residue, the most conserved region among cysteine proteinases, is split by an intron. This is a common characteristic among the gene structures of cysteine proteinases.

【 授权许可】

Unknown