Physiological activation of brown adipose tissue destabilizes thermogenin mRNA

FEBS Letters

Jacobsson, Anders¹  Cannon, Barbara¹  Nedergaard, Jan¹ 

[1] The Wenner-Gren Institute, Biologihus F3, University of Stockholm, S-106 91 Stockholm, Sweden

关键词: mRNA stability;    Nonshivering thermogenesis;    Uncoupling;    Thermogenin;    Norepinephrine;    (Brown adipose tissue);   

DOI  :  10.1016/0014-5793(87)80483-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The amount of mRNA coding for the brown fat specific uncoupling protein thermogenin was followed in the brown adipose tissue of adult mice. As expected, cold exposure or norepinephrine injection caused an increase in the amount of thermogenin mRNA. However, contrary to expectation, the half-life of thermogenin mRNA was dramatically reduced, from about 18 h to about 3 h, when the mice were cold exposed. This destabilization of thermogenin mRNA was not related to the activity of protein synthesis. It was concluded that in brown adipose tissue an unusual mechanism operates which leads to a destabilization of thermogenin mRNA under the same physiological conditions which increase thermogenin gene expression.

【 授权许可】

Unknown