Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

FEBS Letters

Skulachev, Vladimir P.¹ 

[1] Department of Bioenergetics, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119899, USSR

关键词: Fatty acid;    Uncoupling;    ATP/ADP antiporter;    Thermogenin;    Catr;    carboxyatractyloside;    FCCP;    trifluoromethoxycarbonylcyanide phenylhydrazone;   

DOI  :  10.1016/0014-5793(91)80658-P

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Free fatty acids, natural uncouplers of oxidative phosphorylation, are shown to differ from artificial ones in that they fail to increase conductance of phospholipid bilayers which are permeable for the protonated form of fatty acids but impermeable for their anionic form. Recent studies have revealed that uncoupling by fatty acids in mitochondria is mediated by the ATP/ADP antiporter and, in brown fat, by thermogenin which is structurally very similar to the antiporter. It is suggested that both the ATP/ADP antiporter and thermogenin facilitate translocation of the fatty anions through the mitochondrial membrane.

【 授权许可】

Unknown